Lipid Disorders and Mutations in the APOB Gene | Zendy

Amanda Whitfield | Zendy; P. Hugh R. Barrett | Zendy; Frank M. van Bockxmeer | Zendy; John R. Burnett | Zendy

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Lipid Disorders and Mutations in the APOB Gene

Author(s) -

Amanda Whitfield,

P. Hugh R. Barrett,

Frank M. van Bockxmeer,

John R. Burnett

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.038026

Subject(s) - apolipoprotein b , chylomicron , very low density lipoprotein , ldl receptor , familial hypercholesterolemia , microsomal triglyceride transfer protein , apolipoprotein c2 , lipoprotein , biology , medicine , endocrinology , genetics , cholesterol

Plasma lipoproteins are important determinants of atherosclerosis. Apolipoprotein (apo) B is a large, amphipathic glycoprotein that plays a central role in human lipoprotein metabolism. Two forms of apoB are produced from the APOB gene by a unique posttranscriptional editing process: apoB-48, which is required for chylomicron production in the small intestine, and apoB-100, required for VLDL production in the liver. In addition to being the essential structural component of VLDL, apoB-100 is the ligand for LDL-receptor-mediated endocytosis of LDL particles.

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