Serologic Assay Based on Gliadin-Related Nonapeptides as a Highly Sensitive and Specific Diagnostic Aid in Celiac Disease | Zendy

Elke Schwertz | Zendy; Franka Kahlenberg | Zendy; Ulrich Sack | Zendy; Thomas Richter | Zendy; Martin Stern | Zendy; Karsten Conrad | Zendy; KlausPeter Zimmer | Zendy; Thomas Mothes | Zendy

Open Access

Serologic Assay Based on Gliadin-Related Nonapeptides as a Highly Sensitive and Specific Diagnostic Aid in Celiac Disease

Author(s) -

Elke Schwertz,

Franka Kahlenberg,

Ulrich Sack,

Thomas Richter,

Martin Stern,

Karsten Conrad,

KlausPeter Zimmer,

Thomas Mothes

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.036111

Subject(s) - tissue transglutaminase , gliadin , antibody , serology , peptide , autoantibody , chemistry , microbiology and biotechnology , biochemistry , immunology , biology , gluten , enzyme

Celiac disease (CD) is induced by wheat gliadins and related cereal proteins. Anti-gliadin antibodies (AGAs) are present in the serum of CD patients, but these antibodies have lower diagnostic specificity and sensitivity than autoantibodies [anti-endomysium antibodies (AEmAs) and anti-tissue transglutaminase antibodies (AtTGAs)]. Recently, AGAs from CD patients were found to recognize deamidated gliadin peptides, probably formed by the action of tissue transglutaminase.

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