HPLC Retention Time as a Diagnostic Tool for Hemoglobin Variants and Hemoglobinopathies: A Study of 60000 Samples in a Clinical Diagnostic Laboratory | Zendy

Alla Joutovsky | Zendy; Joan Hadzi-Nesic | Zendy; Michael Nardi | Zendy

Open Access

HPLC Retention Time as a Diagnostic Tool for Hemoglobin Variants and Hemoglobinopathies: A Study of 60000 Samples in a Clinical Diagnostic Laboratory

Author(s) -

Alla Joutovsky,

Joan Hadzi-Nesic,

Michael Nardi

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.034991

Subject(s) - retention time , hemoglobin variants , hemoglobin , high performance liquid chromatography , chromatography , chemistry , isoelectric focusing , hemoglobin a2 , hemoglobin f , hemoglobin a , fetal hemoglobin , biology , biochemistry , genetics , pregnancy , fetus , enzyme

Previous evaluations of HPLC as a tool for detection of hemoglobin variants have done so within newborn-screening programs and/or by use of stored samples. We describe a 32-month prospective study in a clinical diagnostic laboratory in which we evaluated the imprecision of HPLC retention times and determined the retention times for hemoglobin variants seen in a multiethnic setting.

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