Immunoassay for Sex Hormone-Binding Globulin in Undiluted Serum Is Influenced by High-Molecular-Mass Aggregates | Zendy

Markus Thaler | Zendy; Jochen Metzger | Zendy; Anita Schreiegg | Zendy; B. Denk | Zendy; Andreas Gleixner | Zendy; Hagen Hauptmann | Zendy; Peter B. Luppa | Zendy

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Immunoassay for Sex Hormone-Binding Globulin in Undiluted Serum Is Influenced by High-Molecular-Mass Aggregates

Author(s) -

Markus Thaler,

Jochen Metzger,

Anita Schreiegg,

B. Denk,

Andreas Gleixner,

Hagen Hauptmann,

Peter B. Luppa

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.034264

Subject(s) - sex hormone binding globulin , immunoassay , chromatography , chemistry , surface plasmon resonance , globulin , dilution , hormone , biochemistry , biology , endocrinology , antibody , androgen , immunology , materials science , physics , nanoparticle , nanotechnology , thermodynamics

The new Elecsys chemiluminescence assay for measurement of homodimeric sex hormone-binding globulin (SHBG) was designed for use with undiluted serum, in contrast to other methods that require predilution. During assay development, unexpected calibration difficulties were observed that were attributable to particular biochemical properties of the highly concentrated SHBG in solution.

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