Molecular Heterogeneity Has a Major Impact on the Measurement of Circulating N-Terminal Fragments of A- and B-Type Natriuretic Peptides | Zendy

Minna AlaKopsala | Zendy; Jarkko Magga | Zendy; Keijo Peuhkurinen | Zendy; Jaana Leipälä | Zendy; Heikki Ruskoaho | Zendy; Juhani Leppäluoto | Zendy; Olli Vuolteenaho | Zendy

Open Access

Molecular Heterogeneity Has a Major Impact on the Measurement of Circulating N-Terminal Fragments of A- and B-Type Natriuretic Peptides

Author(s) -

Minna AlaKopsala,

Jarkko Magga,

Keijo Peuhkurinen,

Jaana Leipälä,

Heikki Ruskoaho,

Juhani Leppäluoto,

Olli Vuolteenaho

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.032490

Subject(s) - natriuretic peptide , myocardial infarction , size exclusion chromatography , medicine , peptide , recombinant dna , endocrinology , chemistry , biochemistry , enzyme , heart failure , gene

The N-terminal fragments of A- and B-type natriuretic peptides (NT-proANP and NT-proBNP) are powerful markers of cardiac function. The current assays require refinement with regard to standardization with native calibrators and the ability to detect the actual circulating forms.

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