Allele-Specific Change of Concentration and Functional Gene Dose for the Prediction of Steady-State Serum Concentrations of Amitriptyline and Nortriptyline in CYP2C19 and CYP2D6 Extensive and Intermediate Metabolizers | Zendy

Werner Steimer | Zendy; Konstanze Zöpf | Zendy; Silvia von Amelunxen | Zendy; Herbert Pfeiffer | Zendy; Julia Bachofer | Zendy; Johannes Popp | Zendy; Barbara Meßner | Zendy; Werner Kissling | Zendy; Stefan Leucht | Zendy

Open Access

Allele-Specific Change of Concentration and Functional Gene Dose for the Prediction of Steady-State Serum Concentrations of Amitriptyline and Nortriptyline in CYP2C19 and CYP2D6 Extensive and Intermediate Metabolizers

Author(s) -

Werner Steimer,

Konstanze Zöpf,

Silvia von Amelunxen,

Herbert Pfeiffer,

Julia Bachofer,

Johannes Popp,

Barbara Meßner,

Werner Kissling,

Stefan Leucht

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.030825

Subject(s) - nortriptyline , cyp2d6 , cyp2c19 , pharmacogenetics , allele , genotype , pharmacology , pharmacokinetics , medicine , biology , chemistry , gene , endocrinology , genetics , amitriptyline

Recently, new polymorphisms were described in connection with intermediate and ultrarapid CYP2D6 metabolism. These may allow a much desired prediction of metabolic activity within the extensive metabolizer group. The functional consequences are still being discussed with few data available for clinical patients.

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