Open AccessSensitive Nonradiometric Method for Determining Thymidine Kinase 1 Activity
Author(s) -
Anders Öhrvik,
Maria Lindh,
R. Einarsson,
Jacques Grassi,
Staffan Eriksson
Publication year - 2004
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2003.030379
Subject(s) - immunoassay , microbiology and biotechnology , thymidine kinase , thymidine , antibody , chemistry , enzyme , medicine , biology , biochemistry , immunology , dna , virus , herpes simplex virus
Thymidine kinase 1 (TK1) is a cytoplasmic enzyme, produced only in the S-phase of proliferating cells, that has potential as a tumor marker. Specific determination of TK1 in serum is difficult, in part because of differences in the physical properties of serum TK1 compared with cytoplasmic TK1.
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