Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms | Zendy

Ying Li | Zendy; Bernhard Zimmermann | Zendy; Corinne Rusterholz | Zendy; Anjeung Kang | Zendy; Wolfgang Holzgreve | Zendy; Sinuhe Hahn | Zendy

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Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms

Author(s) -

Ying Li,

Bernhard Zimmermann,

Corinne Rusterholz,

Anjeung Kang,

Wolfgang Holzgreve,

Sinuhe Hahn

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.029835

Subject(s) - biology , microsatellite , genetics , dna , fetus , agarose gel electrophoresis , genetic marker , microbiology and biotechnology , allele , gene , pregnancy

Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis, particularly for the analysis of fetal genetic traits, which are absent from the maternal genome, e.g., RHD or Y-chromosome-specific sequences. To date, the analysis of other fetal genetic traits has been more problematic because of the overwhelming presence of maternal DNA sequences in the circulation. We examined whether different biochemical properties can be discerned between fetal and maternal circulatory DNA.

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