Open AccessSensitivity and Specificity of Single-Nucleotide Polymorphism Scanning by High-Resolution Melting Analysis
Author(s) -
G. H. Reed,
Carl T. Wittwer
Publication year - 2004
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2003.029751
Subject(s) - single nucleotide polymorphism , high resolution melt , melting curve analysis , biology , snp , genetics , microbiology and biotechnology , polymerase chain reaction , analytical chemistry (journal) , chemistry , genotype , chromatography , gene
Screening for heterozygous sequence changes in PCR products, also known as "mutation scanning", is an important tool for genetic research and clinical applications. Conventional methods require a separation step.
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