Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid A Protein: A Comparison of Monozygotic and Dizygotic Twins | Zendy

Alex J. MacGregor | Zendy; J. Ruth Gallimore | Zendy; Tim D. Spector | Zendy; Mark B. Pepys | Zendy

Open Access

Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid A Protein: A Comparison of Monozygotic and Dizygotic Twins

Author(s) -

Alex J. MacGregor,

J. Ruth Gallimore,

Tim D. Spector,

Mark B. Pepys

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.028258

Subject(s) - c reactive protein , confounding , body mass index , medicine , serum amyloid a protein , population , confidence interval , serum amyloid a , dizygotic twin , acute phase protein , endocrinology , physiology , twin study , biology , heritability , genetics , inflammation , environmental health

C-Reactive protein (CRP) and serum amyloid A protein (SAA) are exquisitely sensitive acute-phase reactants, but their baseline values are surprisingly constant in individuals in the general population. These values, especially of CRP, are associated with future atherothrombotic events, and the determinants of baseline CRP and SAA concentration are therefore of considerable interest.

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