Improved Specificity of Newborn Screening for Congenital Adrenal Hyperplasia by Second-Tier Steroid Profiling Using Tandem Mass Spectrometry | Zendy

Jean M. Lacey | Zendy; Carla Minutti | Zendy; Mark J Magera | Zendy; Angela L. Tauscher | Zendy; Bruno Casetta | Zendy; Mark McCann | Zendy; James Lymp | Zendy; Si Houn Hahn | Zendy; Piero Rinaldo | Zendy; Dietrich Matern | Zendy

Open Access

Improved Specificity of Newborn Screening for Congenital Adrenal Hyperplasia by Second-Tier Steroid Profiling Using Tandem Mass Spectrometry

Author(s) -

Jean M. Lacey,

Carla Minutti,

Mark J Magera,

Angela L. Tauscher,

Bruno Casetta,

Mark McCann,

James Lymp,

Si Houn Hahn,

Piero Rinaldo,

Dietrich Matern

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.027193

Subject(s) - congenital adrenal hyperplasia , steroid , newborn screening , tandem mass spectrometry , profiling (computer programming) , medicine , chemistry , mass spectrometry , endocrinology , chromatography , computer science , pediatrics , hormone , operating system

Newborn screening for congenital adrenal hyperplasia (CAH) involves measurement of 17alpha-hydroxyprogesterone (17-OHP), usually by immunoassay. Because this testing has been characterized by high false-positive rates, we developed a steroid profiling method that uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure 17-OHP, androstenedione, and cortisol simultaneously in blood spots.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research