High-Level Multiplex Genotyping of Polymorphisms Involved in Folate or Homocysteine Metabolism by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry | Zendy

Klaus Meyer | Zendy; Åse Fredriksen | Zendy; Per Magne Ueland | Zendy

Open Access

High-Level Multiplex Genotyping of Polymorphisms Involved in Folate or Homocysteine Metabolism by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Author(s) -

Klaus Meyer,

Åse Fredriksen,

Per Magne Ueland

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.026799

Subject(s) - mtrr , methylenetetrahydrofolate reductase , hyperhomocysteinemia , homocysteine , cystathionine beta synthase , methionine synthase , genotyping , genotype , chemistry , microbiology and biotechnology , multiplex , biology , genetics , biochemistry , methionine , enzyme , gene , cysteine , amino acid

Increased plasma total homocysteine (tHcy), a risk factor for cardiovascular disease, is related to genetic, environmental, and nutritional factors, in particular folate status. Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism.

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