Detection of Hemoglobin-Based Oxygen Carriers in Human Serum for Doping Analysis: Confirmation by Size-Exclusion HPLC | Zendy

Emmanuelle VarletMarie | Zendy; Michael Ashenden | Zendy; Françoise Lasne | Zendy; Marie-Thérèse Sicart | Zendy; Bénédicte Marion | Zendy; J. de Céaurriz | Zendy; Michel Audran | Zendy

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Detection of Hemoglobin-Based Oxygen Carriers in Human Serum for Doping Analysis: Confirmation by Size-Exclusion HPLC

Author(s) -

Emmanuelle VarletMarie,

Michael Ashenden,

Françoise Lasne,

Marie-Thérèse Sicart,

Bénédicte Marion,

J. de Céaurriz,

Michel Audran

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.026591

Subject(s) - hemoglobin , chemistry , blood substitute , chromatography , high performance liquid chromatography , oxygen , biochemistry , organic chemistry

Hemoglobin-based oxygen carriers (HBOCs) are being developed as potential substitutes for the oxygen-carrying functions of erythrocytes, but athletes may obtain and experiment with HBOCs as an illicit means of enhancing oxygen transport. An electrophoretic technique has been developed to screen for the presence of HBOCs in blood samples (Lasne et al. Clin Chem 2004;50:410-5). Interest has focused on complementary methods that can provide legally defensible scientific evidence for the presence of HBOCs in blood samples collected for doping control.

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