Immunopeptidometric Assay for Enzymatically Active Prostate-Specific Antigen | Zendy

Ping Wu | Zendy; Lei Zhu | Zendy; UlfHåkan Stenman | Zendy; Jari Lein | Zendy

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Immunopeptidometric Assay for Enzymatically Active Prostate-Specific Antigen

Author(s) -

Ping Wu,

Lei Zhu,

UlfHåkan Stenman,

Jari Lein

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.026146

Subject(s) - prostate specific antigen , antigen , prostate cancer , antibody , phage display , chemistry , peptide , microbiology and biotechnology , biochemistry , isozyme , enzyme , biology , cancer , immunology , genetics

Determinations of certain forms of prostate-specific antigen (PSA) have been shown to increase the specificity for prostate cancer (PCa). One such variant, proteolytically active PSA, is a potentially useful tumor marker, but it is not specifically recognized by antibodies. Using phage display libraries, we previously identified a "family" of peptides that bind specifically to active PSA. We used these to develop an immunopeptidometric assay (IPMA) that specifically detects this form of PSA.

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