Improvement in Sensitivity of Allele-specific PCR Facilitates Reliable Noninvasive Prenatal Detection of Cystic Fibrosis | Zendy

Ourania Nasis | Zendy; Shanel M. Thompson | Zendy; Tom A. Hong | Zendy; Margaret Sherwood | Zendy; Shawn Radcliffe | Zendy; Laird Jackson | Zendy; Tomas Otevrel | Zendy

Open Access

Improvement in Sensitivity of Allele-specific PCR Facilitates Reliable Noninvasive Prenatal Detection of Cystic Fibrosis

Author(s) -

Ourania Nasis,

Shanel M. Thompson,

Tom A. Hong,

Margaret Sherwood,

Shawn Radcliffe,

Laird Jackson,

Tomas Otevrel

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.025981

Subject(s) - allele , biology , chorionic villus sampling , cystic fibrosis , polymerase chain reaction , microbiology and biotechnology , cold pcr , variants of pcr , mutation , genetics , prenatal diagnosis , taq polymerase , point mutation , fetus , gene , pregnancy , thermus aquaticus

Cell-free fetal DNA circulating in maternal blood has potential as a safer alternative to invasive methods of prenatal testing for paternally inherited genetic alterations, such as cystic fibrosis (CF) mutations.

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