Inductively Coupled Plasma Mass Spectrometric Analysis of Calcium Isotopes in Human Serum: A Low-Sample-Volume Acid-Equilibration Method | Zendy

Zhensheng Chen | Zendy; Ian J. Griffin | Zendy; Yana L. Kriseman | Zendy; Lily K. Liang | Zendy; Steven A. Abrams | Zendy

Open Access

Inductively Coupled Plasma Mass Spectrometric Analysis of Calcium Isotopes in Human Serum: A Low-Sample-Volume Acid-Equilibration Method

Author(s) -

Zhensheng Chen,

Ian J. Griffin,

Yana L. Kriseman,

Lily K. Liang,

Steven A. Abrams

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.025692

Subject(s) - chemistry , oxalate , inductively coupled plasma mass spectrometry , isotopes of calcium , isotope , inductively coupled plasma , calcium , chromatography , mass spectrometry , analytical chemistry (journal) , volume (thermodynamics) , plasma , inorganic chemistry , physics , organic chemistry , quantum mechanics

Analytical methods for measuring the calcium isotope distribution in enriched human serum samples that use low blood volumes, simple preparation methods, and rapid analysis are important in clinical studies of calcium kinetics. Previously, sample preparation by oxalate precipitation typically required 500 micro L of serum. This method was time-consuming, and the blood volume required was limiting in circumstances when only a small amount of serum could be obtained.

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