Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples | Zendy

Glenn E. Palomaki | Zendy; George J. Knight | Zendy; Marie Roberson | Zendy; George C. Cunningham | Zendy; Jo Ellen Lee | Zendy; Charles M. Strom | Zendy; Raj Pandian | Zendy

Open Access

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples

Author(s) -

Glenn E. Palomaki,

George J. Knight,

Marie Roberson,

George C. Cunningham,

Jo Ellen Lee,

Charles M. Strom,

Raj Pandian

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.023986

Subject(s) - human chorionic gonadotropin , urine , trophoblast , observational study , gonadotropin , andrology , antigen , pregnancy , second trimester , gynecology , medicine , obstetrics , endocrinology , biology , placenta , gestation , immunology , hormone , fetus , genetics

Down syndrome screening is commonly performed in the US using maternal age and three or four second-trimester maternal serum markers that can identify up to 75% of affected pregnancies by offering diagnostic studies to 5% of women. Invasive trophoblast antigen [ITA; hyperglycosylated human chorionic gonadotropin (hCG)] is a promising marker that can be measured in urine or serum in the first or second trimester. We report preliminary results for urinary ITA in an ongoing observational study.

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