Pyrosequencing of TPMT Alleles in a General Swedish Population and in Patients with Inflammatory Bowel Disease | Zendy

Sofie Haglund | Zendy; Malin Lindqvist | Zendy; Sven Almér | Zendy; Curt Peterson | Zendy; Jan Taipalensuu | Zendy

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Pyrosequencing of TPMT Alleles in a General Swedish Population and in Patients with Inflammatory Bowel Disease

Author(s) -

Sofie Haglund,

Malin Lindqvist,

Sven Almér,

Curt Peterson,

Jan Taipalensuu

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.023846

Subject(s) - thiopurine methyltransferase , allele , genotype , single nucleotide polymorphism , population , allele frequency , inflammatory bowel disease , genetics , biology , medicine , disease , gene , environmental health

Interindividual differences in therapeutic efficacy in patients treated with thiopurines might be explained by the presence of thiopurine S-methyltransferase (TPMT) alleles that encode for reduced TPMT enzymatic activity. It is therefore of value to know an individual's inherent capacity to express TPMT.

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