Sensitive HPLC-Fluorescence Method for Irinotecan and Four Major Metabolites in Human Plasma and Saliva: Application to Pharmacokinetic Studies | Zendy

Sylvain Poujol | Zendy; Frédéric Pinguet | Zendy; Françoise Malosse | Zendy; Cécile Astre | Zendy; Marc Ychou | Zendy; Stéphane Culine | Zendy; Françoise Bressolle | Zendy

Open Access

Sensitive HPLC-Fluorescence Method for Irinotecan and Four Major Metabolites in Human Plasma and Saliva: Application to Pharmacokinetic Studies

Author(s) -

Sylvain Poujol,

Frédéric Pinguet,

Françoise Malosse,

Cécile Astre,

Marc Ychou,

Stéphane Culine,

Françoise Bressolle

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.023481

Subject(s) - chromatography , chemistry , protein precipitation , pharmacokinetics , high performance liquid chromatography , saliva , analyte , quantitative analysis (chemistry) , extraction (chemistry) , irinotecan , blood plasma , camptothecin , biochemistry , pharmacology , medicine , colorectal cancer , cancer

We developed gradient HPLC methods for quantification of the antimitotic drug irinotecan (CPT-11) and its four metabolites, SN-38, SN-38 G, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]-carbonyloxycamptothecin (APC), and 7-ethyl-10-[4amino-1-piperidino]-carbonyloxycamptothecin (NPC), as the sum of the lactone and carboxylate forms, in human plasma and saliva. Camptothecin was used as internal standard.

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