Rapid Separation of LDL Subclasses by Iodixanol Gradient Ultracentrifugation | Zendy

Ian G. Davies | Zendy; John M. Graham | Zendy; Bruce A. Griffin | Zendy

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Rapid Separation of LDL Subclasses by Iodixanol Gradient Ultracentrifugation

Author(s) -

Ian G. Davies,

John M. Graham,

Bruce A. Griffin

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.023366

Subject(s) - iodixanol , chemistry , chromatography , density gradient , centrifugation , analytical chemistry (journal) , medicine , physics , quantum mechanics , contrast medium , radiology

A predominance of small, dense LDL (sdLDL) confers in excess of a threefold increase in coronary heart disease (CHD) risk. The conventional method for the detection of sdLDL, salt density gradient ultracentrifugation (DGUC) has been superseded by more rapid techniques. This report presents novel methodology for the separation of sdLDL by a combination of iodixanol density gradient centrifugation and digital photography.

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