Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns | Zendy

Donald H. Chace | Zendy; Theodore A. Kalas | Zendy; Edwin W. Naylor | Zendy

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Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns

Author(s) -

Donald H. Chace,

Theodore A. Kalas,

Edwin W. Naylor

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.022178

Subject(s) - newborn screening , tandem mass spectrometry , dried blood , metabolite , metabolomics , amino acid analysis , amino acid metabolism , metabolic disease , mass spectrometry , computational biology , chemistry , medicine , computer science , amino acid , chromatography , biochemistry , biology

Over the past decade laboratories that test for metabolic disorders have introduced tandem mass spectrometry (MS/MS), which is more sensitive, specific, reliable, and comprehensive than traditional assays, into their newborn-screening programs. MS/MS is rapidly replacing these one-analysis, one-metabolite, one-disease classic screening techniques with a one-analysis, many-metabolites, many-diseases approach that also facilitates the ability to add new disorders to existing newborn-screening panels.

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