Amino-Terminal Form of Parathyroid Hormone (PTH) with Immunologic Similarities to hPTH(1–84) Is Overproduced in Primary and Secondary Hyperparathyroidism | Zendy

P D'Amour | Zendy; JeanHugues Brossard | Zendy; Louise Rousseau | Zendy; Louise Roy | Zendy; Ping Gao | Zendy; Tom Cantor | Zendy

Open Access

Amino-Terminal Form of Parathyroid Hormone (PTH) with Immunologic Similarities to hPTH(1–84) Is Overproduced in Primary and Secondary Hyperparathyroidism

Author(s) -

P D'Amour,

JeanHugues Brossard,

Louise Rousseau,

Louise Roy,

Ping Gao,

Tom Cantor

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.021592

Subject(s) - parathyroid hormone , medicine , primary hyperparathyroidism , endocrinology , chemistry , hyperparathyroidism , secondary hyperparathyroidism , calcium

To separate non-(1-84)parathyroid hormone [non-(1-84)PTH] from PTH(1-84), we developed new HPLC gradients and observed that the peak coeluting with hPTH(1-84) could be separated into two entities recognized by a cyclase-activating PTH (CA-PTH) assay that reacts with the first four amino acids of the PTH structure.

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