N-Acetylated Metabolites in Urine: Proton Nuclear Magnetic Resonance Spectroscopic Study on Patients with Inborn Errors of Metabolism | Zendy

Udo F. H. Engelke | Zendy; M.L.F. Liebrand-van Sambeek | Zendy; J.G.N. de Jong | Zendy; Jules G. Leroy | Zendy; Éva Morava | Zendy; Jan A. M. Smeitink | Zendy; Ron A. Wevers | Zendy

Open Access

N-Acetylated Metabolites in Urine: Proton Nuclear Magnetic Resonance Spectroscopic Study on Patients with Inborn Errors of Metabolism

Author(s) -

Udo F. H. Engelke,

M.L.F. Liebrand-van Sambeek,

J.G.N. de Jong,

Jules G. Leroy,

Éva Morava,

Jan A. M. Smeitink,

Ron A. Wevers

Publication year - 2004

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2003.020214

Subject(s) - urine , chemistry , acetylation , metabolism , nuclear magnetic resonance spectroscopy , metabolite , inborn error of metabolism , creatinine , proton nmr , chromatography , nuclear magnetic resonance , biochemistry , stereochemistry , physics , gene

There is no comprehensive analytical technique to analyze N-acetylated metabolites in urine. Many of these compounds are involved in inborn errors of metabolism. In the present study, we examined the potential of proton nuclear magnetic resonance ((1)H-NMR) spectroscopy as a tool to identify and quantify N-acetylated metabolites in urine of patients with various inborn errors of metabolism.

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