Detection of Chromosome 21-encoded mRNA of Placental Origin in Maternal Plasma | Zendy

Cees B.M. Oudejans | Zendy; Attie T. J. J. Go | Zendy; Allerdien Visser | Zendy; Monique A. M. Mulders | Zendy; Bart A. Westerman | Zendy; Marinus A. Blankenstein | Zendy; J. M. G. van Vugt | Zendy

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Detection of Chromosome 21-encoded mRNA of Placental Origin in Maternal Plasma

Author(s) -

Cees B.M. Oudejans,

Attie T. J. J. Go,

Allerdien Visser,

Monique A. M. Mulders,

Bart A. Westerman,

Marinus A. Blankenstein,

J. M. G. van Vugt

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.9.1445

Subject(s) - human placental lactogen , placenta , placental lactogen , biology , microbiology and biotechnology , messenger rna , aneuploidy , pregnancy associated plasma protein a , trisomy , rna , gene , gene expression , chromosome , human chorionic gonadotropin , rna extraction , andrology , fetus , pregnancy , genetics , first trimester , medicine

mRNA of placental origin (i.e., human placental lactogen and beta-human chorionic gonadotropin) has been demonstrated to be easily detectable in maternal plasma. We tested whether detection of chromosome 21-encoded mRNA of placental origin is possible in maternal plasma obtained during the first trimester.

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