Butyrylcholinesterase (BCHE) Genotyping for Post-Succinylcholine Apnea in an Australian Population | Zendy

Tina Yen | Zendy; Brian N. Nightingale | Zendy; Jennifer Burns | Zendy; David R. Sullivan | Zendy; Peter Stewart | Zendy

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Butyrylcholinesterase (BCHE) Genotyping for Post-Succinylcholine Apnea in an Australian Population

Author(s) -

Tina Yen,

Brian N. Nightingale,

Jennifer Burns,

David R. Sullivan,

Peter Stewart

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.8.1297

Subject(s) - butyrylcholinesterase , genotyping , population , medicine , genotype , chemistry , biology , genetics , biochemistry , environmental health , enzyme , gene , acetylcholinesterase , aché

Measurement of plasma butyrylcholinesterase (BChE) activity and inhibitor-based phenotyping are standard methods for identifying patients who experience post-succinylcholine (SC) apnea attributable to inherited variants of the BChE enzyme. Our aim was to develop PCR-based assays for BCHE mutation detection and implement them for routine diagnostic use at a university teaching hospital.

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