Open AccessIdentification of Rat Targets of Anti-Soluble Liver Antigen Autoantibodies by Serologic Proteome Analysis
Author(s) -
Éric Ballot,
Arnaud Bruneel,
Valérie Labas,
Catherine Johanet
Publication year - 2003
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/49.4.634
Subject(s) - serology , autoantibody , proteome , antigen , identification (biology) , antibody , immunology , microbiology and biotechnology , biology , biochemistry , botany
Anti-soluble liver antigen (SLA) autoantibodies are specific for autoimmune hepatitis type 1 and are the only immunologic marker found in 15-20% of hepatitis cases previously considered cryptogenic. Anti-SLA antibodies react with the 100 000g supernatant from rat liver homogenate, but the molecular targets remain controversial.
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