Catecholamine-Synthesizing Enzymes in Carcinoid Tumors and Pheochromocytomas | Zendy

Wim G. Meijer | Zendy; Sjef Copray | Zendy; Harry Hollema | Zendy; Ido P. Kema | Zendy; Nynke Zwart | Zendy; Ietje Mantingh-Otter | Zendy; Thera P. Links | Zendy; Pax H.B. Willemse | Zendy; Elisabeth G.E. de Vries | Zendy

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Catecholamine-Synthesizing Enzymes in Carcinoid Tumors and Pheochromocytomas

Author(s) -

Wim G. Meijer,

Sjef Copray,

Harry Hollema,

Ido P. Kema,

Nynke Zwart,

Ietje Mantingh-Otter,

Thera P. Links,

Pax H.B. Willemse,

Elisabeth G.E. de Vries

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.4.586

Subject(s) - pheochromocytoma , endocrinology , medicine , tyrosine hydroxylase , catecholamine , phenylethanolamine n methyltransferase , tryptophan hydroxylase , carcinoid tumors , biology , phenylethanolamine , serotonin , dopamine , receptor , serotonergic

Serotonin is the principal endocrine product of carcinoid tumors, but simultaneously increased production of catecholamines has been described in these tumors. As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT)] in midgut carcinoid tumors and pheochromocytoma and to correlate enzyme expression to serotonin production as well as catecholamines and metabolites excreted in urine.

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