Open AccessToxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis
Author(s) -
Rita De Smet,
Jacqueline Van Kaer,
Bruno Van Vlem,
Antoine De Cubber,
Philippe Brunet,
Norbert Lameire,
Raymond Vanholder
Publication year - 2003
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/49.3.470
Subject(s) - p cresol , free fraction , clearance , medicine , albumin , toxicity , chemistry , cresol , serum albumin , endocrinology , pharmacokinetics , phenol , urology , organic chemistry
Uremic syndrome is the consequence of the retention of solutes usually cleared by the healthy kidneys. p-Cresol can be considered a prototypic protein-bound uremic toxin. It is conceivable, analogous with drugs, that the non-protein-bound fraction of p-cresol exerts toxicity. This aspect had never been evaluated, nor have the factors influencing the free fraction of p-cresol.
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