Effect of Riboflavin Status on the Homocysteine-lowering Effect of Folate in Relation to the MTHFR (C677T) Genotype | Zendy

Stuart J. Moat | Zendy; Pauline AshfieldWatt | Zendy; Hilary J. Powers | Zendy; Robert G. Newcombe | Zendy; I.F.W. McDowell | Zendy

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Effect of Riboflavin Status on the Homocysteine-lowering Effect of Folate in Relation to the MTHFR (C677T) Genotype

Author(s) -

Stuart J. Moat,

Pauline AshfieldWatt,

Hilary J. Powers,

Robert G. Newcombe,

I.F.W. McDowell

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.2.295

Subject(s) - methylenetetrahydrofolate reductase , riboflavin , homocysteine , medicine , endocrinology , thermolabile , b vitamins , vitamin , chemistry , reductase , genotype , biochemistry , enzyme , gene

Riboflavin (vitamin B(2)) is the precursor for FAD, the cofactor for methylenetetrahydrofolate reductase (MTHFR). MTHFR catalyzes the formation of 5-methyltetrahydrofolate, which acts as a methyl donor for homocysteine remethylation. Individuals with the MTHFR 677C-->T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status. It has been proposed that riboflavin may act together with folate to lower plasma tHcy, particularly in individuals with the thermolabile MTHFR T variant.

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