Evaluation of Cell-free Fetal DNA as a Second-Trimester Maternal Serum Marker of Down Syndrome Pregnancy | Zendy

Antonio Farina | Zendy; Erik S LeShane | Zendy; Geralyn LambertMesserlian | Zendy; Jacob A. Canick | Zendy; Thomas Lee | Zendy; Louis M. Neveux | Zendy; Glenn E. Palomaki | Zendy; Diana W. Bianchi | Zendy

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Evaluation of Cell-free Fetal DNA as a Second-Trimester Maternal Serum Marker of Down Syndrome Pregnancy

Author(s) -

Antonio Farina,

Erik S LeShane,

Geralyn LambertMesserlian,

Jacob A. Canick,

Thomas Lee,

Louis M. Neveux,

Glenn E. Palomaki,

Diana W. Bianchi

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.2.239

Subject(s) - cell free fetal dna , fetus , pregnancy , gestational age , andrology , medicine , obstetrics , population , down syndrome , prenatal diagnosis , biology , genetics , psychiatry , environmental health

Second-trimester cell-free fetal DNA (studied only in pregnancies with male fetuses) is higher in maternal serum samples from women carrying Down syndrome fetuses than in unaffected pregnancies. In this study we evaluated the potential performance of fetal DNA as a screening marker for Down syndrome.

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