Rapid Detection of Flt3 Mutations in Acute Myeloid Leukemia Patients by Denaturing HPLC | Zendy

Michele Bianchini | Zendy; Emanuela Ottaviani | Zendy; Tiziana Grafone | Zendy; Barbara Giannini | Zendy; Simona Soverini | Zendy; Carolina Terragna | Zendy; Marilina Amabile | Zendy; Pier Paolo Piccaluga | Zendy; Michele Malagola | Zendy; Michela Rondoni | Zendy; Costanza Bosi | Zendy; Michele Baccarani | Zendy; Giovanni Martinelli | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Rapid Detection of Flt3 Mutations in Acute Myeloid Leukemia Patients by Denaturing HPLC

Author(s) -

Michele Bianchini,

Emanuela Ottaviani,

Tiziana Grafone,

Barbara Giannini,

Simona Soverini,

Carolina Terragna,

Marilina Amabile,

Pier Paolo Piccaluga,

Michele Malagola,

Michela Rondoni,

Costanza Bosi,

Michele Baccarani,

Giovanni Martinelli

Publication year - 2003

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/49.10.1642

Subject(s) - myeloid leukemia , high performance liquid chromatography , myeloid , leukemia , chemistry , chromatography , medicine , cancer research

fms-related tyrosine kinase 3 (Flt3) is the most commonly mutated gene in human acute myeloid leukemia (AML) and has been implicated in its pathogenesis. Because screening of Flt3 in AML patients by PCR followed by gel electrophoresis is time-consuming and fails to detect some very small internal tandem duplications (ITDs), we developed a method for screening of FLT3 receptor mutations with PCR plus denaturing HPLC (D-HPLC).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research