Open AccessOptimized Strategy for Rapid Cytochrome P450 2D6 Genotyping by Real-Time Long PCR
Author(s) -
Burkhardt Müller,
Konstanze Zöpf,
Julia Bachofer,
Werner Steimer
Publication year - 2003
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/49.10.1624
Subject(s) - genotyping , ethidium bromide , agarose gel electrophoresis , biology , variants of pcr , microbiology and biotechnology , cyp2d6 , real time polymerase chain reaction , polymerase chain reaction , genotype , gene duplication , genetics , gene , dna
Because of genetic polymorphisms, cytochrome P450 2D6 (Cyp2D6) activity in humans varies widely and alters the metabolism of commonly used drugs such as antidepressants, neuroleptics, and cardioactive agents. Severe adverse effects or resistance to therapy may result.
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