Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections | Zendy

Julia A. Messina | Zendy; Joshua T. Thaden | Zendy; Batu K. SharmaKuinkel | Zendy; Vance G. Fowler | Zendy

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Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections

Author(s) -

Julia A. Messina,

Joshua T. Thaden,

Batu K. SharmaKuinkel,

Vance G. Fowler

Publication year - 2016

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1005330

Subject(s) - staphylococcus aureus , microbiology and biotechnology , biology , genetic variation , staphylococcal infections , bacteria , genetics , gene

The clinical diversity of syndromes caused by Staphylococcus aureus arises from a complex interplay between host and pathogen. Genetic variation can result in increased susceptibility to infection within the host and an increased capacity for virulence within the pathogen, resulting in a wide array of clinical syndromes. This review presents evidence for the role of bacterial and human genetic variation in influencing the clinical outcome of S. aureus infections.

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