Silent Prions and Covert Prion Transmission | Zendy

Candace K. Mathiason | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Silent Prions and Covert Prion Transmission

Author(s) -

Candace K. Mathiason

Publication year - 2015

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1005249

Subject(s) - scrapie , virology , biology , chronic wasting disease , incubation period , slow virus , infectivity , fatal familial insomnia , disease , bovine spongiform encephalopathy , transmission (telecommunications) , kuru , infectious disease (medical specialty) , virus , medicine , prion protein , viral disease , pathology , incubation , biochemistry , electrical engineering , engineering

Prions are infectious agents with zoonotic potential that cause progressive neurodegenerative diseases, known as the transmissible spongiform encephalopathies (TSEs), in animals and humans. Prion disease can be initiated by a spontaneous event, handed down within families from generation to generation through genetic inheritance, or transmitted between susceptible hosts via direct exchange of bodily fluids and/or excreta (saliva, blood, urine, and feces), indirect contact with contaminated environments (bedding, buckets, soils, water), or during medical intervention (transfusion, dura mater grafts, human growth hormone, contaminated instruments) [1–3]. Observation and study of prion diseases has led to an understanding that transmission dynamics and efficiency varies among prions, dependent upon agent strain, inoculation route, and host factors/genetics [1,2].

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research