HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1 | Zendy

Nuria IzquierdoUseros | Zendy; Maier Lorizate | Zendy; Paul J. McLaren | Zendy; Amalio Telenti | Zendy; HansGeorg Kräusslich | Zendy; Javier MartínezPicado | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

Author(s) -

Nuria IzquierdoUseros,

Maier Lorizate,

Paul J. McLaren,

Amalio Telenti,

HansGeorg Kräusslich,

Javier MartínezPicado

Publication year - 2014

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1004146

Subject(s) - dc sign , siglec , microbiology and biotechnology , biology , lectin , dendritic cell , human immunodeficiency virus (hiv) , viral entry , viral infection , virology , immunology , virus , viral replication , immune system

Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans -infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans -infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research