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α-(1,3)-Glucan is a major component of the cell wall of  Aspergillus fumigatus , an opportunistic human fungal pathogen. There are three genes ( AGS1 ,  AGS2  and  AGS3 ) controlling the biosynthesis of α-(1,3)-glucan in this fungal species. Deletion of all the three  AGS  genes resulted in a triple mutant that was devoid of α-(1,3)-glucan in its cell wall; however, its growth and germination was identical to that of the parental strain  in vitro . In the experimental murine aspergillosis model, this mutant was less pathogenic than the parental strain. The  AGS  deletion resulted in an extensive structural modification of the conidial cell wall, especially conidial surface where the rodlet layer was covered by an amorphous glycoprotein matrix. This surface modification was responsible for viability reduction of conidia  in vivo , which explains decrease in the virulence of triple  ags Δ mutant.

plos pathogens

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus