Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms | Zendy

Petr Brož | Zendy; Denise M. Monack | Zendy

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Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

Author(s) -

Petr Brož,

Denise M. Monack

Publication year - 2013

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1003144

Subject(s) - effector , microbiology and biotechnology , nlrp1 , inflammasome , chemistry , caspase 8 , caspase , immunology , biology , apoptosis , inflammation , programmed cell death , biochemistry

Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1. Recently, a new noncanonical inflammasome pathway has been described that activates caspase-11, an understudied pro-inflammatory caspase. Despite new insights into the signaling events that control caspase-11 activation, a number of unanswered questions remain..

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