Genital Tract Sequestration of SIV following Acute Infection | Zendy

James B. Whitney | Zendy; Peter Hraber | Zendy; Corinne Luedemann | Zendy; Elena E. Giorgi | Zendy; Marcus Daniels | Zendy; Tanmoy Bhattacharya | Zendy; Srinivas S. Rao | Zendy; John R. Mascola | Zendy; Gary J. Nabel | Zendy; Bette Korber | Zendy; Norman L. Letvin | Zendy

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Genital Tract Sequestration of SIV following Acute Infection

Author(s) -

James B. Whitney,

Peter Hraber,

Corinne Luedemann,

Elena E. Giorgi,

Marcus Daniels,

Tanmoy Bhattacharya,

Srinivas S. Rao,

John R. Mascola,

Gary J. Nabel,

Bette Korber,

Norman L. Letvin

Publication year - 2011

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1001293

Subject(s) - viremia , simian immunodeficiency virus , biology , virology , virus , semen , genital tract , immunology , viral replication , viral load , physiology , genetics

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus “spillover” into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

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