Autoimmunity as a Predisposition for Infectious Diseases | Zendy

Mohan S. Maddur | Zendy; Janakiraman Vani | Zendy; Sébastien LacroixDesmazes | Zendy; Srini V. Kaveri | Zendy; Jagadeesh Bayry | Zendy

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Autoimmunity as a Predisposition for Infectious Diseases

Author(s) -

Mohan S. Maddur,

Janakiraman Vani,

Sébastien LacroixDesmazes,

Srini V. Kaveri,

Jagadeesh Bayry

Publication year - 2010

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1001077

Subject(s) - autoimmunity , immunology , autoantibody , pathogenesis , genetic predisposition , immune system , inflammation , biology , self tolerance , genetics , gene , antibody

Autoimmunity refers to an inappropriate immune response against self-components of the host that results in pathological conditions. Autoimmune diseases are characterized by an activation of autoreactive T and B cells, are associated in some cases with the production of pathogenic autoantibodies against self-molecules, culminating in inflammation and tissue damage. The reasons for the breakdown of tolerance mechanisms leading to autoimmunity are not clearly known. However, a combination of genetic, immunological, and environmental factors plays a critical role in the pathogenesis of autoimmunity [1]–[5].

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