The Great Escape: Viral Strategies to Counter BST-2/Tetherin | Zendy

Janet L. Douglas | Zendy; Jean K. Gustin | Zendy; Kasinath Viswanathan | Zendy; Mandana Mansouri | Zendy; Ashlee V. Moses | Zendy; Klaus Früh | Zendy

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The Great Escape: Viral Strategies to Counter BST-2/Tetherin

Author(s) -

Janet L. Douglas,

Jean K. Gustin,

Kasinath Viswanathan,

Mandana Mansouri,

Ashlee V. Moses,

Klaus Früh

Publication year - 2010

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1000913

Subject(s) - tetherin , virology , biology , virus , ebola virus , interferon , viral envelope , viral replication , viral protein , human immunodeficiency virus (hiv) , microbiology and biotechnology

The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma–associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as “tetherin”. However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.

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