Enzymatic Properties of the Neuraminidase of Seasonal H1N1 Influenza Viruses Provide Insights for the Emergence of Natural Resistance to Oseltamivir | Zendy

MarieAnne RameixWelti | Zendy; Vincent Enouf | Zendy; Frédérique Cuvelier | Zendy; Patricia Jeannin | Zendy; Sylvie van der Werf | Zendy

Open Access

Enzymatic Properties of the Neuraminidase of Seasonal H1N1 Influenza Viruses Provide Insights for the Emergence of Natural Resistance to Oseltamivir

Author(s) -

MarieAnne RameixWelti,

Vincent Enouf,

Frédérique Cuvelier,

Patricia Jeannin,

Sylvie van der Werf

Publication year - 2008

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.1000103

Subject(s) - oseltamivir , neuraminidase , neuraminidase inhibitor , virology , enzyme , biology , seasonal influenza , influenza a virus , h5n1 genetic structure , virus , covid-19 , medicine , biochemistry , infectious disease (medical specialty) , disease

Surveillance of the antiviral susceptibility of influenza viruses in Europe revealed the emergence of influenza A(H1N1) viruses naturally resistant to the anti-neuraminidase inhibitor oseltamivir (Tamiflu) [1]. Currently, resistant viruses are most prevalent in Europe (25%) but less prevalent in the Americas (16%) or the Western Pacific region (4%) [2]. In Europe, the prevalence varies between countries, with highest levels in Norway (66.5%) and France (46.6%) [3]. These frequencies are in sharp contrast with those observed for H1N1 viruses during previous seasons (0 to <1%) [4]–[8].

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