A Novel Linear Plasmid Mediates Flagellar Variation in Salmonella Typhi | Zendy

Stephen Baker | Zendy; Jonathan Hardy | Zendy; Kenneth E. Sanderson | Zendy; Michael A. Quail | Zendy; Ian Goodhead | Zendy; Robert A. Kingsley | Zendy; Julian Parkhill | Zendy; B. A. D. Stocker | Zendy; Gordon Dougan | Zendy

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A Novel Linear Plasmid Mediates Flagellar Variation in Salmonella Typhi

Author(s) -

Stephen Baker,

Jonathan Hardy,

Kenneth E. Sanderson,

Michael A. Quail,

Ian Goodhead,

Robert A. Kingsley,

Julian Parkhill,

B. A. D. Stocker,

Gordon Dougan

Publication year - 2007

Publication title -

plos pathogens

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.719

H-Index - 206

eISSN - 1553-7374

pISSN - 1553-7366

DOI - 10.1371/journal.ppat.0030059

Subject(s) - flagellin , salmonella typhi , plasmid , biology , microbiology and biotechnology , salmonella enterica , salmonella , enterobacteriaceae , typhoid fever , bacteriophage , gene , virology , genetics , bacteria , escherichia coli

Unlike the majority of Salmonella enterica serovars, Salmonella Typhi ( S . Typhi), the etiological agent of human typhoid, is monophasic. S . Typhi normally harbours only the phase 1 flagellin gene (fliC), which encodes the H:d antigen. However, some S . Typhi strains found in Indonesia express an additional flagellin antigen termed H:z66. Molecular analysis of H:z66+ S . Typhi revealed that the H:z66 flagellin structural gene (fljB z66 ) is encoded on a linear plasmid that we have named pBSSB1. The DNA sequence of pBSSB1 was determined to be just over 27 kbp, and was predicted to encode 33 coding sequences. To our knowledge, pBSSB1 is the first non-bacteriophage–related linear plasmid to be described in the Enterobacteriaceae.

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