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We showed previously that  eiger,  the  Drosophila  tumor necrosis factor homolog, contributes to the pathology induced by infection with  Salmonella typhimurium . We were curious whether  eiger  is always detrimental in the context of infection or if it plays a role in fighting some types of microbes. We challenged wild-type and  eiger  mutant flies with a collection of facultative intracellular and extracellular pathogens, including a fungus and Gram-positive and Gram-negative bacteria. The response of  eiger  mutants divided these microbes into two groups:  eiger  mutants are immunocompromised with respect to extracellular pathogens but show no change or reduced sensitivity to facultative intracellular pathogens. Hence,  eiger  helps fight infections but also can cause pathology. We propose that  eiger  activates the cellular immune response of the fly to aid clearance of extracellular pathogens. Intracellular pathogens, which can already defeat professional phagocytes, are unaffected by  eiger .

Drosophila eiger Mutants Are Sensitive to Extracellular Pathogens