English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives  To explore associations between exposures to medicines prescribed for asthma and their discontinuation in pregnancy and preterm birth [<37 or <32 weeks], SGA [<10th and <3rd centiles], and breastfeeding at 6–8 weeks.    Methods   Design.  A population-based cohort study.   Setting.  The Secure Anonymised Information Linkage [SAIL] databank in Wales, linking maternal primary care data with infant outcomes.   Population.  107,573, 105,331, and 38,725 infants born 2000–2010 with information on premature birth, SGA and breastfeeding respectively, after exclusions.   Exposures.  maternal prescriptions for asthma medicines or their discontinuation in pregnancy.   Methods.  Odds ratios for adverse pregnancy outcomes were calculated for the exposed  versus  the unexposed population, adjusted for smoking, parity, age and socio-economic status.    Results  Prescriptions for asthma, whether continued or discontinued during pregnancy, were associated with birth at<32 weeks’ gestation, SGA <10th centile, and no breastfeeding (aOR 1.33 [1.10–1.61], 1.10 [1.03–1.18], 0.93 [0.87–1.01]). Discontinuation of asthma medicines in pregnancy was associated with birth at<37 weeks’ and <32 weeks’ gestation (aOR 1.22 [1.06–1.41], 1.53 [1.11–2.10]). All medicines examined, except ICS and SABA prescribed alone, were associated with SGA <10th centile.    Conclusions  Prescription of asthma medicines before or during pregnancy was associated with higher prevalence of adverse perinatal outcomes, particularly if prescriptions were discontinued during pregnancy. Women discontinuing medicines during pregnancy could be identified from prescription records. The impact of targeting close monitoring and breastfeeding support warrants exploration.

Medicines prescribed for asthma, discontinuation and perinatal outcomes, including breastfeeding: A population cohort analysis