The inclusion of blastomeres into the inner cell mass in early-stage human embryos depends on the sequence of cell cleavages during the fourth division | Zendy

Junko Otsuki | Zendy; Toshiroh Iwasaki | Zendy; Noritoshi Enatsu | Zendy; Yuya Katada | Zendy; Kohyu Furuhashi | Zendy; Masahide Shiotani | Zendy

Open Access

The inclusion of blastomeres into the inner cell mass in early-stage human embryos depends on the sequence of cell cleavages during the fourth division

Author(s) -

Junko Otsuki,

Toshiroh Iwasaki,

Noritoshi Enatsu,

Yuya Katada,

Kohyu Furuhashi,

Masahide Shiotani

Publication year - 2020

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0240936

Subject(s) - blastomere , cell division , embryo , biology , microbiology and biotechnology , inner cell mass , developmental biology , cell fate determination , cleave , cell , embryogenesis , genetics , blastocyst , gene , transcription factor , dna

The fate of the ICM in humans is still unknown, due to the ethical difficulties surrounding experimentation in this field. In this study we have explored the existing time-lapse recording data of embryos in the early stages of development, taking advantage of the large refractile bodies (RBs) within blastomeres as cellular markers. Our study found that the cellular composition of the ICM in humans is largely determined at the time of the fourth division and blastomeres which cleave first to fourth, during the fourth division from 8 cells to 16 cells, have the potential to be incorporated in the ICM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research