Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis | Zendy

Élcio Leal | Zendy; Ruiying Liang | Zendy; Qi Liu | Zendy; Fabiola Villanova | Zendy; Lijun Shi | Zendy; Lin Liang | Zendy; Jinxiang Li | Zendy; Steven S. Witkin | Zendy; Shangjin Cui | Zendy

Open Access

Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis

Author(s) -

Élcio Leal,

Ruiying Liang,

Qi Liu,

Fabiola Villanova,

Lijun Shi,

Lin Liang,

Jinxiang Li,

Steven S. Witkin,

Shangjin Cui

Publication year - 2020

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0227705

Subject(s) - cats , biology , virology , parvovirus , genome , virus , phylogenetic tree , polymerase chain reaction , canine parvovirus , mink , genetics , gene , medicine , ecology

Protoparvoviruses, widespread among cats and wild animals, are responsible for leukopenia. Feline panleukopenia virus (FPLV) in domestic cats is genetically diverse and some strains may differ from those used for vaccination. The presence of FPLV in two domestic cats from Hebei Province in China was identified by polymerase chain reaction. Samples from these animals were used to isolate FPLV strains in CRFK cells for genome sequencing. Phylogenetic analysis was performed to compare our isolates with available sequences of FPLV, mink parvovirus (MEV) and canine parvovirus (CPV). The isolated strains were closely related to strains of FPLV/MEV isolated in the 1960s. Our analysis also revealed that the evolutionary history of FPLV and MEV is characterized by local adaptations in the Vp2 gene. Thus, it is likely that new FPLV strains are emerging to evade the anti-FPLV immune response.

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