Open AccessThe role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children—Analyses based on path models
Author(s) -
Maike Wolters,
Carmen Dering,
Alfonso Siani,
Paola Russo,
Jaakko Kaprio,
Patrizia Risé,
Luís A. Moreno,
Stefaan De Henauw,
Kirsten Mehlig,
Toomas Veidebaum,
Dénes Molnár,
Michael Tornaritis,
Licia Iacoviello,
Yannis Pitsiladis,
Claudio Galli,
Ronja Foraita,
Claudia Börnhorst
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0181485
Subject(s) - body mass index , polyunsaturated fatty acid , blood pressure , medicine , obesity , eicosapentaenoic acid , arachidonic acid , endocrinology , fatty acid , biology , biochemistry , enzyme
Background The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. Methods A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (T
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