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Purpose  The aim of this study was to detect and assess the estrogen receptor (ESR) coactivator  PELP1  expression within human paraspinal skeletal muscles in patients suffering from idiopathic scoliosis.    Methods  During surgical correction of scoliosis the muscle biopsies harvested in 29 females. Presence of  PELP1 ,  ESR1  and  ESR2  genes transcripts was studied using RT-qPCR technique while immunohistochemistry and western blot methods were used to detect the PEPL1 protein presence.    Results   PELP1  expression in deep paraspinal muscles revealed higher than in superficial back muscles (p = 0.005). Positive immunohistochemical staining for PELP1 was observed in the nuclei of the paraspinal muscle cells. Western blot revealed PELP1 protein in all samples. No significant difference in  PELP1  expression between the convex and the concave scoliosis side (p>0.05) was found. In deep paraspinal back muscles, a significant correlation between the  PELP1  expression level on the concave side and the Cobb angle (r = 0.4; p<0.05) was noted as well as between the  PELP1  and  ESR1  expression level (r = 0.7; p<0.05) while no correlation between  PELP1  and  ESR2  expression level was found.    Conclusion  To our knowledge, three techniques for the first time demonstrated the presence of the PELP1 in paraspinal muscles of patients with idiopathic scoliosis. The PELP1 potential regulatory impact on back muscle function is to be further investigated.

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Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis