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Mycoplasma infection in human and its contamination in cell cultures are worldwide problems. The drugs currently available for preventing or treating mycoplasma infection suffer from low sensitivity, strong resistance and high toxicity. Our previous work showed that  Mycoplasma hyorhinis  ( M .  hyorhinis ) infection was mediated by the interaction between p37 of  M .  hyorhinis  and Annexin A2 (ANXA2) of host cells, however the translational value of this mechanism was unknown. Herein, we synthesized the N-terminal of ANXA2 polypeptide (A2PP) and found that A2PP could decrease the infection of  M .  hyorhinis  to gastric cancer cells and block  M .  hyorhinis  infection-induced cell migration. Furthermore, we found that A2PP could reduce  M .  hyorhinis  contamination of passage cells. Moreover, compared with the commercial antibiotics commonly used in cell culture to prevent  M .  hyorhinis  infection, A2PP demonstrated a more effectiveness but a low toxicity on cell growth. Thus, our study for the first time revealed A2PP’s potential for the treatment and prevention of  M .  hyorhinis  infection.

N-Terminal Polypeptide of Annexin A2 Decreases Infection of Mycoplasma hyorhinis to Gastric Cancer Cells