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125 I seeds coated with titanium are considered a safe and effective interstitial brachytherapy for tumors, while the cost of  125 I seeds is a major problem for the patients implanting lots of seeds. The aim of this paper was to develop a novel silicone coating for  125 I seeds with a lower cost. In order to show the radionuclide utilization ratio, the silicone was coated onto the seeds using the electro-spinning method and the radioactivity was evaluated, then the anti-tumor efficacy of silicone  125 I seeds was compared with titanium  125 I seeds. The seeds were divided into four groups: A (control), B (pure silicone), C (silicone  125 I), D (titanium  125 I) at 2 Gy or 4 Gy. Their anti-tumour activity and mechanism were assessed in vitro and in vivo using a human extrahepatic cholangiocarcinoma cell line FRH-0201 and tumor-bearing BALB/c nude mice. The silicone  125 I seeds showed higher radioactivity; the rate of cell apoptosis in vitro and the histopathology in vivo demonstrated that the silicone  125 I seeds shared similar anti-tumor efficacy with the titanium  125 I seeds for the treatment of extrahepatic cholangiocarcinoma, while they have a much lower cost.

Novel Silicone-Coated 125I Seeds for the Treatment of Extrahepatic Cholangiocarcinoma